Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.
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چکیده
منابع مشابه
Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.
Extensive utilization of pesticides against insects provides us with a good model for studying the adaptation of a eukaryotic genome to a strong selective pressure. One mechanism of resistance is the alteration of acetylcholinesterase (EC 3.1.1.7), the molecular target for organophosphates and carbamates. Here, we report the sequence analysis of the Ace gene in several resistant field strains o...
متن کاملIdentification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase involved in insecticide resistance.
Acetylcholinesterase (AChE) insensitive to organophosphate and carbamate insecticides has been identified as a major resistance mechanism in numerous arthropod species. However, the associated genetic changes have been reported in the AChE genes from only three insect species; their role in conferring insecticide insensitivity has been confirmed, using functional expression, only for those in D...
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Gene duplication is thought to be the main potential source of material for the evolution of new gene functions. Several models have been proposed for the evolution of new functions through duplication, most based on ancient events (Myr). We provide molecular evidence for the occurrence of several (at least 3) independent duplications of the ace-1 locus in the mosquito Culex pipiens, selected i...
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Insecticide resistance is an increasing problem faced by those who need insecticides to efficiently control medical, veterinary and agricultural insect pests. In many insects, the problem extends to all major groups of insecticides. Since the first case of DDT resistance in 1947, the incidence of resistance has increased annually at an alarming rate. It has been estimated that there are at leas...
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Fleas are the major ectoparasite of cats, dogs, and rodents worldwide and potential vectors of animal diseases. In the past two decades the majority of new control treatments have been either topically applied or orally administered to the host. Most reports concerning the development of insecticide resistance deal with the cat flea, Ctenocephalides felis felis. Historically, insecticide resist...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.13.5922